Mutation
Domain : Pathophysiology
Category : Learn more
Simplified definition
Changes that occur in one or more genes and that can affect the functioning of an individual’s body or their physical traits.
Source: Houria Aiouaz, for Alzheimer Foundation
Referenced definition
“Mutation refers to any change in the nucleotide sequence as a result of a failure of the system to revert the change. Thus, the altered sequence is permanent and heritable.”
Source: Biology Online. Mutation. [Internet]. [cited on May 8, 2023].
Context
“Mutations can result from errors in DNA replication during cell division, exposure to mutagens or a viral infection.”
Source: National Human Genome Research Institute. Mutation. [Internet]. 2023 [cited on May 8, 2023].
Note
- Depending on the type of mutation and the cells affected, it may lead to different consequences, such as hereditary diseases, organ dysfunction, or cancers.