Tau

Category : My daily life

Simplified definition

A protein found inside the neurons and that stabilizes their internal structure, their skeleton.

Source: Houria Aiouaz, for Alzheimer Foundation

Referenced definition

“Tau is a microtubule-associated protein, which is widely expressed in the central nervous system, predominantly in neurons, where it regulates microtubule dynamics, axonal transport, and neurite outgrowth.”
Source: Chambraud B, Sardin E, Giustiniani J, Baulieu EE. A role for FKBP52 in Tau protein function. PNAS. 2010;107(6):2658-2663.

Context

“Neurodegenerative diseases with abnormal tau inclusions are referred to as tauopathies, including Alzheimer disease (AD), frontotemporal dementia with parkinsonism-17 (FTDP-17), Pick disease (PiD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).”

Source: Gao YL, Wang N, Sun FR, Cao XP, Zhang W, Yu JT. Tau in neurodegenerative disease. Annals of Translational Medicine. 2018;6(10):175.

Note

  • “Tau” stands for “Tubulin-associated unit”.
  • In Alzheimer deases, Tau proteins detach from a neuron’s skeleton (microtubules), accumulate inside the neuron, and form tangles, which causes that skeleton to fall apart, prevents the neuron from making connections with other neurons, and leads to its death.

Synonym(s)

Microtubule associated protein Tau

Abbreviation(s)

MAPT

Tau : RELATED DEFINITIONS

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