Neuroinflammation

Category : My daily life

Simplified definition

Inflammation in the brain caused by the buildup of cells that are supposed to clear the brain from the accumulation of abnormal proteins. In Alzheimer’s, these cells accumulate and end up killing the neurons.

Source: Houria Aiouaz, for Alzheimer Foundation

Referenced definition

“[…] Inflammatory response within the brain or spinal cord.”

Source: DiSabato DJ, Quan N, Godbout JP. Neuroinflammation: the devil is in the details. Journal of Neurochemistry. 2016;139(2):136-153.

Context

Neuroinflammation represents a key process in many neurodegenerative disorders, including Alzheimer disease (AD), the most common neurodegenerative disorder in the elderly.”

Source: Regen F, Hellmann-Regen J, Costantini E, Reale M. Neuroinflammation and Alzheimer’s disease: implications for microglial activation. Current Alzheimer Research. 2017;14:1-9.

Note

  • Neuroinflammation does not occur only in Alzheimer’s.
  • Brain inflammation can be beneficial, but it can become harmful when it is excessive.
  • High levels of proteins called “cytokines” may be observed in cerebrospinal fluid during the diagnosis of Alzheimer disease.

Synonym(s)

Brain inflammation

Spelling variation(s)

Neuro-inflammation

Neuroinflammation : RELATED DEFINITIONS

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