Cholinesterase inhibitors

Domain : Support

Simplified definition

A class of drugs that prevent the destruction of a molecule called “acetylcholine”, thus increasing its concentration in the body and the communication between neurons.

Source: Houria Aiouaz, for Alzheimer Foundation

Referenced definition

“[…] Chemicals whose primary toxic effect is to block the normal breakdown of the neurotransmitter, acetylcholine.”

Source: ATSDR. Part 2: What are cholinesterase inhibitors. [Internet]. [cited on Sept 7, 2022]. 


Cholinesterase inhibitors are the most common medications used for the symptomatic treatment of Alzheimer disease. Data from published clinical trials have shown benefits for cognitive, behavioral, and functional outcomes.”

Source: Lee PE, Hsiung GYR, Seitz D, Gill SS, Rochon PA. Cholinesterase inhibitors. BC Medical Journal. 2011;53(8):404-408.




  • Acetylcholine is involved in memory and moves information from a neuron to another.
  • An elevated concentration of acetylcholine in the body can be harmful.


Acetylcholinesterase inhibitors / Anticholinesterase drugs

Cholinesterase inhibitors : RELATED DEFINITIONS


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