Apolipoprotein E

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Simplified definition

A protein whose role is to carry lipids (fats), such as cholesterol, to the neurons to feed them.

Source: Houria Aiouaz, for Alzheimer Foundation

Referenced definition

“Apolipoprotein E (APOE) is a glycoprotein involved in cholesterol homeostasis and lipid metabolism, that is produced mainly by hepatocytes and astrocytes, and is found in plasma and cerebrospinal fluid.”

Source: Lumsden AL, Mulugeta A, Zhou A, Hypponen E. Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank. EBioMedicine. 2020;59.

Context

“APOE polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk: individuals carrying the ε4 allele are at increased risk of AD compared with those carrying the more common ε3 allele, whereas the ε2 allele decreases risk.”

Source: Nat Rev Neurol. 2013 Feb; 9(2): 106–118.

 

Note

  • Apolipoprotein E is produced by a gene located on chromosome 19.
  • The ε4 variant of the gene coding for apolipoprotein E is a risk factor for Alzheimer’s disease.

Synonym(s)

APOE

Apolipoprotein E : RELATED DEFINITIONS

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