APOE4

Category : Pathophysiology

Simplified definition

A version of the gene encoding a protein called apolipoprotein E. It is a genetic risk factor for Alzheimer’s disease.

Source: Houria Aiouaz, for Alzheimer Foundation

Referenced definition

“[…] An isoform of the APOE gene in humans […].”

Source: Najm R, Jones EA, Huang Y. Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease. Molecular Neurodegeneration. 2019;14.

Context

“The APOE4 allele, present in approximately 10-15% of people, increases the risk for Alzheimer’s and lowers the age of onset. Having one copy of E4 (E3/E4) can increase your risk by 2 to 3 times while two copies (E4/E4) can increase the risk by 12 times.”

Source: Cognitive Vitality. What APOE means for your health. [Internet]. Nov 16, 2016 [cited on Sept 7, 2022]. 

Note

  • “APOE4” stands for “Apolipoprotein E4”.
  • A version of a gene is called an “allele”.

Spelling variation(s)

ApoE4

APOE4 : RELATED DEFINITIONS

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